9,2

Scientific Research

The secret for best clinical practice

Meniscus: Kniespecialist RPA Janssen is topspecialist in behandeling van meniscus in de knie. Voorste kruisband op maat. Kniespecialist RPA Janssen
Read more →

2 presentations of Digital twin Knee at ICMS Symposium 2021

Link to presentations

Read more →

First prize for joint ACL research Orthopaedics Maxima Medical Center & Eindhoven University of Technology

Marc van Vijven wins first prize for...

Read more →

9 presentations at Scientific Meeting 2021 Máxima MC

Nine scientific presentations by the...

Follow me!

Remain up to date with all the latest knee facts via Facebook, Twitter and other social networks


Assessment of graft maturity after anterior cruciate ligament reconstruction using autografts:a systematic review of biopsy and MRI studies

Assessment of graft maturity after anterior cruciate ligament reconstruction using autografts:a systematic review of biopsy and MRI studies

B. van Groningen, M. C. van der Steen, D. M. Janssen, L. W. van Rhijn, T. van der Linden, R. P. A. Janssen
Orthopaedic Proceedings VOLUME 103-B, ISSUE SUPP_4 / MARCH 2021 (a supplement to the Bone and Joint Journal

The purpose of this investigation was to evaluate systematically the literature concerning biopsy, MRI signal to noise quotient (SNQ) and clinical outcomes in graft-maturity assessment after autograft anterior cruciate ligament reconstruction (ACLR) and their possible relationships. Methods: The systematic review was reported and conducted according to the PRISMA (Preferred Reporting Items for Systematic reviews and Meta-Analyses) guidelines. Studies through May 2019 evaluating methods of intra-articular ACL autograft maturity assessment were considered for inclusion. Eligible methods were histologic studies of biopsy specimens and conventional MRI studies reporting serial SNQ and/ or correlation with clinical parameters. Ten biopsy studies and 13 imaging studies, with a total of 706 patients, met the inclusion criteria. Biopsy studies show that graft remodeling undergoes an early healing phase, a phase of remodeling or proliferation and a ligamentization phase as an ongoing process even 1 year after surgery. Imaging studies showed an initial increase in SNQ, peaking at approximately 6 months, followed by a gradual decrease over time. There is no evident correlation between graft SNQ and knee stability outcome scores at the short- and long-term follow-up after ACLR. The remodeling of the graft is an ongoing process even 1 year after ACLR, based on human biopsy studies. MRI SNQ peaked at approximately 6 months, followed by a gradual decrease over time. Heterogeneity of the MRI methods and technical restrictions used in the current literature limit prediction of graft maturity and clinical and functional outcome measures by means of MRI graft SNQ after ACLR.


← Back to publications

 

RPA Janssen, MD PhD Prof
Orthopaedic Surgeon
Orthopaedic Associates Eindhoven Greater Area
Orthopedic Center Máxima
Máxima Medical Center (MMC)

Visiting adress MMC Eindhoven:
Ds. Th. Fliednerstraat 1
Ingang Zuid
5631 BM  Eindhoven
The Netherlands 
(outpatient clinic and surgery)

Visiting adress MMC Veldhoven:
De Run 4600
5504 DB  Veldhoven
The Netherlands
(Outpatient clinic)

Mail adress:
Postbus 90052
5600 PD  Eindhoven
The Netherlands

Tel. 0031 (0)40 88 88 600
(Call center Orthopedie)

Fax: 0031 (0)40 88 85 938
www.rpajanssen.com 

Links:
KneeGuru
Orthopaedic Associates Eindhoven Greater Area
Máxima Medical Center
Eindhoven University of Technology
Fontys University of Applied Sciences
 

RPA Janssen YouTube
RPA Janssen Twitter
RPA Janssen Facebook
RPA Janssen LinkedIn
RPA Janssen weblog




s2